Cell-based assays

At Rodon Biologics, we offer specialized cell-based assays to accurately and reliably assess the biological activity of compounds. Our services cover a broad range of applications, providing a deep understanding of the interactions between compounds and biological systems, accelerating the development of your therapeutics. These assays are essential for modeling cellular behavior and understanding dynamic life processes, which are crucial for drug development.

Cell-based assays are essential in modern drug discovery and development, providing critical data on a compound’s efficacy, potency, and safety in a biologically relevant environment. With a wide array of cell types available—including primary cells, immortalized cell lines, human blood cells, and customized transfected cell lines—we are equipped to deliver tailored assay solutions that meet your unique project needs.

These assays allow for real-time evaluation of cellular responses, providing clear evidence of their effectiveness. They are indispensable in the development of biologics, vaccines, and small molecules, offering the support needed throughout every phase of your project.

Key Assay Types and Applications

• Ligand-Receptor Binding: Our assays evaluate the binding efficiency between ligands and their receptors, helping you understand the mechanism of action of your compounds.
• Cell Proliferation: We assess the effect of compounds on cell growth, a critical aspect in cancer research and regenerative medicine.
• Cytotoxicity and Apoptosis Assays: By measuring cell death and survival, we evaluate compound-induced cytotoxicity, apoptosis, and immunological responses (e.g., ADCC, T-cell mediated cytotoxicity).
• Reporter Gene Assays: These assays measure the activation of specific signaling pathways, providing insights into gene expression modulation and the effectiveness of targeted therapies.
• Cellular Differentiation: We study the differentiation of primary or progenitor cells into specialized cell types, which is key for understanding regenerative medicine and tissue engineering.
• Immune Cell Activation and Proliferation: We assess immune responses, which are essential for immunotherapy and vaccine development.
• Cytokine Release and Biomarker Expression: Understanding the cytokine profile and biomarker expression patterns can aid in the evaluation of immunomodulatory therapies.

Our services extend to both early-stage discovery and later stages of development, ensuring that you have reliable data at every phase of your project. Whether you are developing biologics, vaccines, or small molecules, we offer the support you need to take your project from the lab to clinical trials.

Immunotherapy Drug Evaluation Expertise

Immunomodulatory therapies, particularly in immunochemistry, play a crucial role in developing effective treatments. At Rodon Biologics, we specialize in evaluating immunotherapies using advanced methodologies like NOEL (No Observed Effect Level) and MABEL (Minimal Anticipated Biological Effect Level). These approaches are vital for determining the safe and effective dose of monoclonal antibodies and other immunotherapeutics, ensuring both safety and optimal biological response.

Our expertise goes beyond basic evaluations. We investigate the intricate mechanisms of action (MOA) of these therapies, offering unique insights into their interaction with immune cells and their impact on cellular responses. By leveraging cutting-edge biochemical assays, we assess gene expression modulation and protein activity, which are key to understanding immune-related pathways.

Commitment to Quality and Precision

At Rodon Biologics, we prioritize consistency and quality across all assays. Our experts utilize rigorous methodologies and integrate the latest technologies to deliver accurate, reproducible results aligned with your project goals. Conducted in our state-of-the-art Biosafety Level 2 (BSL-2) labs, all assays comply with international regulatory standards.

We combine scientific expertise with innovative technologies to provide comprehensive, high-quality bioactivity assays. Whether you need customized assays or wish to discuss how we can support your research, our team is here to assist you.

Contact Us Today

Ready to accelerate your drug development? Reach out to our team today to discuss how our specialized cell-based assays can support your therapeutic projects.